Receptor usage by the Acanthocheilonema viteae-derived immunomodulator, ES-62
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چکیده
منابع مشابه
Receptor usage by the Acanthocheilonema viteae-derived immunomodulator, ES-62.
ES-62 is an immunomodulatory phosphorylcholine (PC)-containing glycoprotein secreted by the rodent filarial nematode Acanthocheilonema viteae. Previously, the use of knockout mice has revealed the effects of ES-62 on macrophages and dendritic cells to be dependent on TLR4. However, it is possible that ES-62 may interact with additional proteins on the surfaces of target cells and hence that cel...
متن کاملTesting small molecule analogues of the Acanthocheilonema viteae immunomodulator ES‐62 against clinically relevant allergens
ES-62 is a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that protects against ovalbumin (OVA)-induced airway hyper-responsiveness in mice by virtue of covalently attached anti-inflammatory phosphorylcholine (PC) residues. We have recently generated a library of small molecule analogues (SMAs) of ES-62 based around its active PC moiety as a starting point in novel drug...
متن کاملMast Cell Subsets and Their Functional Modulation by the Acanthocheilonema viteae Product ES-62
ES-62, an immunomodulator secreted by filarial nematodes, exhibits therapeutic potential in mouse models of allergic inflammation, at least in part by inducing the desensitisation of Fc ε RI-mediated mast cell responses. However, in addition to their pathogenic roles in allergic and autoimmune diseases, mast cells are important in fighting infection, wound healing, and resolving inflammation, r...
متن کاملModulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae.
Parasite survival and host health may depend on the ability of the parasite to modulate the host immune response by the release of immunomodulatory molecules. Excretory-secretory (ES)-62, one such well-defined molecule, is a major secreted protein of the rodent filarial nematode Acanthocheilonema viteae, and has homologues in human filarial nematodes. Previously we have shown that ES-62 is excl...
متن کاملProtective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation
ES-62 is the major secreted protein of the rodent filarial nematode Acanthocheilonema viteae. The molecule contains covalently attached phosphorylcholine (PC) residues, which confer anti-inflammatory properties on ES-62, underpinning the idea that drugs based on this active moiety may have therapeutic potential in human diseases associated with aberrant inflammation. Here we demonstrate that tw...
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ژورنال
عنوان ژورنال: Experimental Parasitology
سال: 2012
ISSN: 0014-4894
DOI: 10.1016/j.exppara.2011.09.001